Endocrine Abstracts

Introduction: Topoisomerase II alpha is regarded as the important marker of cellular proliferation. Pituitary tumours are usually benign, but some of them are characterized by rapid growth, high recurrence rate and local invasiveness. Proliferation marker Ki-67 most commonly used in pituitary tumours is not entirely reliable as the indicator of the aggressive growth of the lesion. Topoisomerase II alpha expression assessment may be a valuable tool for identification such pitui...

Background: TSH-secreting tumors appears as extremely rare cause of hyperthyroidism. Major clinical feature is preserved TSH level in subjects with apparent thyrotoxicosis. Misdiagnosis of primary thyroid hyper function led to mistreatment with anti-thyroid agents. This worsens disease course and outcome. Neurosurgery success rate is limited by large tumor size and extrasellular expansion. Somatostatin plays key role in regulation of TSH secretion. Tumors in most cases express...

Background: Double pituitary adenomas are a rare entity, which requires clinical attention and a careful follow-up.Case report: A 37-year-old man presented with left-sided painful gynecomastia. He denied typical symptoms of excessive growth hormone (GH) secretion and did not show any acromegalic features. Due to low testosterone and LH levels with mild hyperprolactinaemia, the patient was referred to pituitary MR, which revealed an 11 × 13 mm right-...

Introduction: The patients with inoperable hormone - secreting pituitary tumours are treated with cold somatostatin analogues, but it is not always effective. DOTA-TATE preparation is a somatostatin analogue coupled with β (−) emitter 90 Y. The efficacy of the treatment is based on excessive expression of somatostatin receptors (SSTR) in these tumours.The aim of the study: To assess the feasibility of treatment of pituitary tumours ...

Background: Neuroendocrine neoplasms (NENs) are rare group of tumors with a different clinical course, prognosis and location. Radioligand therapy (RLT) is currently registered in gastroenteropancreatic (GEP) G1-G2 NENs. Tumors with an unknown point of origin, diagnosed outside the gastrointestinal tract and pancreas, or with Ki-67 >20%, do not qualify in many countries to standard RLT.Materials and Methods: 48 patients with progressive NENs of unkno...

Isolated sarcoidosis of the hypothalamic-pituitary system is a very rare form of neurosarcoidosis. It usually leads to secondary damage to endocrine function, resulting in hypopituitarism and diabetes insipidus. A 32-year-old male patient with progressive deterioration of his general condition, weakness, polyuria, dizziness and visual field disturbances was admitted to the Department of Endocrinology for the diagnosis of a tumor in the hypothalamic-pituitary region. MRI showed...

Background: A significant body of research indicates that transgender and gender-nonconforming persons represent an underserved population susceptible to health care disparities. The attitudes and knowledge of medical doctors toward transgender people have important implications for the future quality of healthcare for transgender patients.Specific Aim: The aim of this study was an assessment of coverage of transgender care issues in training curricula o...

Primary hyperparathyroidism (PHP) diagnosis in clinical practice is based on biochemical blood tests. Since a single parathyroid adenoma causes about 85% of cases, the treatment of choice is parathyroidectomy, preceded by imaging studies. Ultrasound and [99mTc]sestamibi scanning can enable adenoma localization. However, the latter method is of higher sensitivity, especially if combined with anatomical imaging. In some cases, the radiotracer uptake in adenoma tissue ...

Objectives: Endogenous Cushing’s Syndrome (CS) is a rare, chronic condition that results in high morbidity, caused by prolonged exposure to elevated levels of circulating free cortisol levels. Osilodrostat, a newly approved steroidogenesis inhibitor, has been shown to achieve fast and high rates of cortisol normalization, improving manifestations of hypercortisolism in patients with Cushing’s Disease (CD), a form of CS. We evaluated relative complete response (CR) ou...

Background: Bilateral adrenalectomy (BLA) is a treatment option for patients suffering from endogenous Cushing syndrome (CS). It consists of the surgical removal of both adrenal glands. Even though BLA offers immediate control of cortisol excess, given the risk of adrenal insufficiency, it requires life-long glucocorticoid and mineral corticoid replacement. It may lead to perioperative and long-term complications which affect patients’ quality of life (QoL). Health state ...